One step syntheses of hypoxanthines from 2-cyano-2-phenylazoacetamides.
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چکیده
منابع مشابه
One Step Synthesis of 6-Amino-5-Cyano-4-Phenyl-2-Mercapto Pyrimidine Using Phosphorus Pentoxide
A simple and efficient approach towards one step synthesis of 6-amino-5-cyano-4-phenyl-2-mercapto pyrimidine and its hydroxyl derivatives have been developed by three component condensation of aromatic aldehydes, malononitrile and thiourea/urea in presence of phosphorus pentoxide (Scheme 1).
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In the crystal structure of the title compound, C(5)H(8)N(2)O, mol-ecules are linked via pairs of N-H⋯O hydrogen bonds, forming inversion dimers. These dimers are linked via pairs of N-H⋯H hydrogen bonds into zigzag chains propagating along [101].
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There have been major advances reported over the past decade in previously untreated chronic lymphocytic leukemia (CLL) with chemo-immunotherapy approaches now the treatment of choice.2 A decade ago, chlorambucil was the treatment of choice. However, CLL is a disease of the elderly with a median age at diagnosis of 72 years, and almost 70% of CLL patients are older than 65 years at the time of ...
متن کامل1-[(Z)-2-Cyano-2-(2-pyridyl)vinyl]ferrocene
In the title compound, [Fe(C(5)H(5))(C(13)H(9)N(2))], the dihedral angle between the substituted cyclo-penta-dienyl plane and the plane of the pyridine ring is 8.43 (14)°. The double bond adopts a Z configuration. In the crystal structure, weak C-H⋯N inter-actions link the molecules into a zigzag chain. A weak intramolecular C-H⋯N hydrogen bond is also present.
متن کامل2-Cyano-N,N-dimethylacetamide
In the crystal structure of the title compound, C(5)H(8)N(2)O, mol-ecules are linked by weak C-H⋯O hydrogen bonds, forming a three-dimensional network.
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1975
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.23.2401